TABLE 3.
Tag SNPs from Caucasian HapMap genotype data and the association of SNP genotypes with liver AKR1D1 mRNA expression
The r2 threshold for tag SNPs analysis was 0.8. A dash indicates that the SNP was not genotyped.
| Group | Minor Allele Frequency | TAG SNPs | Location in Gene | Hepatic AKR1D1 mRNA Association |
|---|---|---|---|---|
| % | P | |||
| 1 | 23 | rs2120846 | Intron 1 | 0.045 |
| rs6977075 | Intron 2 | — | ||
| rs6980334 | Intron 4 | — | ||
| rs7795946 | Intron 4 | — | ||
| 2 | 43 | rs8180809 | Intron 3 | 0.14 |
| 3 | 21 | rs1872929 | 3′ UTR | 0.003 |
| rs1872930 | 3′ UTR | 0.003 | ||
| rs2035647 | Intron 8 | — | ||
| rs2306847 | Intron 8 | — | ||
| 4 | 18 | rs2306846 | Intron 6 | — |
| rs3805362 | Intron 7 | 0.17 | ||
| rs12668157 | Intron 1 | — | ||
| 5 | 7 | rs6943935 | Intron 2 | — |
| rs17169518 | Intron 7 | 0.53 | ||
| rs17169521 | Intron 8 | 0.22 | ||
| 6 | 37 | rs2035648 | Intron 8 | 0.1 |
| 7 | 3 | rs2306845 | Intron 4 | 0.9 |
| 8 | 3 | rs2882947 | Intron 7 | — |
| 9 | 17 | rs3735023 | 3′ UTR | 0.87 |
| 10 | 13 | rs6467735 | Intron 4 | 0.26 |
| 11 | 1 | rs17169523 | 3′ UTR | — |
| 12 | 11 | rs17543126 | Intron 4 | — |