Table 1. Summary of murine vaccination experiments comparing immunogenicity of PLGA/PLA particles encapsulating Ag (+/−adjuvant).

Compared sizes	Polymer	Vaccination route	Cargo	Results summary		References
				Output	Optimum size(s)
500 nm, 2 μm, and 7 μm	PLGA 50:50	IP	OVA	Th1 + CTL responses	500 nm	41
300 nm, 1 μm, 7 μm, and 17 μm	PLGA 50:50	IP	OVA and CpG	IgG2a + CTL responses	300 nm	35
200 nm, 500 nm, and 1 μm	PLGA 50:50	subQ or Oral	BSA	IgG responses	1 μm	43
200–600 nm vs 2–8 μm	PLA	IM	HBsAg	Th1 responses	200–600 nm	44
				Th2 responses	2–8 μm
50–150 μm, 10–70 μm, 2–8 μm and < 2 μm	PLA	IM	Tetanus Toxoid	IgG responses	2–8 μm	45
1 μm and 5 μm	PLGA 50:50	Oral	BSA	IgG responses	1 μm	46

IP, intraperitoneal; subQ, subcutaneous; IM, intramuscular; HBsAg, hepatitis B surface antigen; CTL, cytotoxic T lymphocyte.