Table 1.
Clinical characteristics of patients with cohesin family gene defects
| Mutants (n = 93) | WT (n = 687) | P | |
|---|---|---|---|
| Age | 65 (24-91) | 63 (18-91) | |
| >60 y | 72 | 504 | |
| <60 y | 21 | 183 | .45 |
| Sex | |||
| Male | 58 | 426 | |
| Female | 35 | 261 | 1 |
| Diagnosis | |||
| MDS-low | 22 | 190 | |
| MDS-high/sAML | 52 | 219 | .0036 |
| MDS/MPN | 7 | 147 | |
| MPN | 3 | 50 | |
| pAML | 9 | 93 | |
| IPSS* | |||
| Low | 8 | 99 | .05 |
| Int-1 | 20 | 106 | |
| Int-2 | 10 | 57 | |
| High | 4 | 19 | |
| Karyotype† | |||
| Normal | 56 (48%) | 351 (45%) | .1 |
| Abnormal | 60 (53%) | 425 (54%) | .1 |
| Complex | 11 (10%) | 104 (13%) | .36 |
| −5/del(5q) | 4 (4%) | 89 (11%) | .007 |
| −7/del(7q) | 4 (4%) | 99 (13%) | .002 |
| Trisomy 8 | 22 (19%) | 69 (9%) | .004 |
| −20/del(20q) | 6 (5%) | 45 (6%) | 1 |
| OS (mo) | 27.2 | 39.9 | .02 |
*
n = 42 (mutants), 281 (WT).
†
n = 116 (mutants), 776 (WT).