| Variables | Total population (n=25 519) | 5-Year interval |
Relative change (difference, %) | p for trend1 | ||
|---|---|---|---|---|---|---|
| 1994-1999 (n=8539) | 2000-2005 (n=9729) | 2006-2010 (n=7251) | ||||
| Total population | ||||||
| Framingham risk score | 7.0 (3.3) | 7.4 (3.2) | 7.1 (3.3) | 6.5 (3.2) | -0.9 | < 0.001 |
| 10-Year CVD risk (%) | 11.0 (7.0,18.0) | 11.0 (8.0,18.0) | 11.0 (7.0,18.0) | 11.0 (7.0,14.0) | 0 | < 0.001 |
| Age (y) | 66.5 (12.1) | 65.5 (11.8) | 66.9 (12.1) | 67.2 (12.3) | 1.7 | < 0.001 |
| Male gender | 18 068 (71.0) | 6041 (71.0) | 6861 (71.0) | 5166 (71.0) | 0 | 0.52 |
| SBP (mmHg) | 128.8 (22.1) | 136.8 (21.9) | 131.2 (22.4) | 121.9 (19.7) | -14.9 | < 0.001 |
| DBP (mmHg) | 70.2 (13.4) | 75.6 (12.5) | 70.6 (13.4) | 67.1 (13.0) | -8.5 | < 0.001 |
| Hypertension | 17 785 (72.0) | 5095 (61.0) | 6982 (75.0) | 5708 (82.0) | 21 | < 0.001 |
| LDL (mg/dL) | 104.3 (38.5) | 119.7 (37.5) | 101.6 (36.5) | 94.0 (37.8) | -25.7 | < 0.001 |
| TC (mg/dL) | 177.4 (45.8) | 194.1 (45.0) | 174.9 (42.1) | 165.8 (46.9) | -28.3 | < 0.001 |
| HDL (mg/dL) | 43.6 (12.8) | 42.5 (12.3) | 44.2 (12.6) | 43.7 (13.4) | 1.2 | < 0.001 |
| DM | 6564 (26.0) | 1891 (22.0) | 2574 (27.0) | 2099 (29.0) | 7 | < 0.001 |
| Current smoker | 4527 (18.0) | 1582 (19.0) | 1650 (17.0) | 1295 (18.0) | -1 | 0.22 |
| Ever smoker | 16 088 (63.0) | 5431 (64.0) | 6134 (63.0) | 4523 (62.0) | -2 | 0.11 |
| Men | ||||||
| Framingham risk score | 6.3 (2.6) | 6.5 (2.5) | 6.4 (2.7) | 6.0 (2.5) | -0.5 | < 0.001 |
| 10-Year CVD risk (%) | 11.0 (9.0,18.0) | 14 (9.0,18.0) | 11. (9.0,18.0) | 11.0 (7.0,18.0) | -3 | < 0.001 |
| Age (y) | 65.3 (11.8) | 64.2 (11.5) | 65.6 (11.8) | 66.0 (12.0) | 1.8 | < 0.001 |
| SBP (mmHg) | 128.2 (21.4) | 135.4 (21.2) | 130.6 (21.9) | 121.7 (19.1) | -13.7 | < 0.001 |
| DBP (mmHg) | 71.3 (13.0) | 76.3 (12.3) | 71.4 (13.1) | 68.6 (12.6) | -7.7 | < 0.001 |
| Hypertension | 12 078 (69.0) | 3355 (57.0) | 4733 (73.0) | 3990 (80.0) | 23 | < 0.001 |
| LDL (mg/dL) | 103.2 (37.4) | 118.4 (35.6) | 100.7 (35.8) | 92.4 (36.6) | -26 | < 0.001 |
| TC (mg/dL) | 174.0 (44.8) | 190.3 (43.5) | 171.6 (40.8) | 162.1 (46.5) | -28.2 | < 0.001 |
| HDL (mg/dL) | 41.4 (11.4) | 40.5 (10.8) | 42.0 (11.2) | 41.4 (12.0) | 0.9 | < 0.001 |
| DM | 4319 (24.0) | 1163 (19.0) | 1723 (25.0) | 1433 (28.0) | 9 | < 0.001 |
| Current smoker | 3324 (18.0) | 1170 (19.0) | 1206 (18.0) | 948 (18.0) | -1 | 0.14 |
| Ever smoker | 12 542 (69.0) | 4286 (71.0) | 4750 (69.0) | 3506 (68.0) | -3 | < 0.001 |
| Women | ||||||
| Framingham risk score | 8.9 (4.0) | 9.6 (3.6) | 8.9 (4.0) | 8.0 (4.2) | -1.6 | < 0.001 |
| 10-Year CVD risk (%) | 9.0 (7.0,15.0) | 9.0 (8.0,15.0) | 9.0 (6.0,15.0) | 8.0 (5.0,13.0) | -1 | < 0.001 |
| Age (y) | 69.5 (12.2) | 68.7 (11.7) | 69.9 (12.4) | 70.0 (12.7) | 1.3 | < 0.001 |
| SBP (mmHg) | 130.3 (23.6) | 140.6 (23.5) | 132.6 (23.6) | 122.6 (21.1) | -18 | < 0.001 |
| DBP (mmHg) | 67.5 (14.0) | 73.7 (13.0) | 68.4 (13.8) | 63.3 (13.5) | -10.4 | < 0.001 |
| Hypertension | 5707 (79.0) | 1,740 (71.0) | 2249 (82.0) | 1718 (85.0) | 14 | < 0.001 |
| LDL (mg/dL) | 107.1 (41.1) | 123.3 (41.9) | 103.8 (38.0) | 97.9 (40.4) | -25.4 | < 0.001 |
| TC (mg/dL) | 186.2 (47.2) | 204.7 (47.3) | 182.9 (44.1) | 175.0 (46.7) | -29.7 | < 0.001 |
| HDL (mg/dL) | 49.2 (14.4) | 47.8 (14.2) | 49.8 (14.1) | 49.6 (14.8) | 1.8 | < 0.001 |
| DM | 2245 (30.0) | 728 (29.0) | 851 (30.0) | 666 (32.0) | 3 | 0.04 |
| Current smoker | 1203 (16.0) | 412 (16.0) | 444 (15.0) | 347 (17.0) | 1 | 0.95 |
| Ever smoker | 3546 (48.0) | 1145 (46.0) | 1384 (48.0) | 1017 (49.0) | 3 | 0.042 |
Values are presented as mean±SD, number of patients (%), or median (quartiles 1, 3).
CVD, cardiovascular disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low density lipoprotein; TC, total cholesterol; HDL, high density lipoprotein; DM, diabetic mellitus.
1
A linear regression analysis was used to assess the trend for continuous variables, and the Cochran-Armitage trend test was used for the comparison of proportions.