Table 2.
Genotypic associations with anatomical outcome measures at one year (N=835).
| SNP | Genotype | N | Retinal Thickness in microns (%) | Mean change of total foveal thickness from baseline in microns (SE) | Dry on OCT (%) | Leakage on FA (%) | Mean change in lesion size from baseline in disc area (SE) | ||
|---|---|---|---|---|---|---|---|---|---|
| <120 | 120–212 | >212 | |||||||
|
VEGF-A rs699946 |
AA | 535 | 106 (20.3) | 356 (68.1) | 61 (11.7) | −59.1 (4.8) | 150 (29.0) | 227 (44.7) | 0.2 (0.1) |
| AG | 269 | 56 (21.0) | 183 (68.5) | 28 (10.5) | −61.2 (7.4) | 78 (29.9) | 125 (49.6) | 0.3 (0.2) | |
| GG | 31 | 6 (19.4) | 23 (74.2) | 2 (6.5) | −49.1 (15.3) | 11 (37.9) | 13 (43.3) | 0.3 (0.3) | |
| Linear Trend P§ | 0.59 | 0.92 | 0.44 | 0.38 | 0.38 | ||||
|
VEGF-A rs699947 |
AA | 201 | 33 (17.0) | 129 (66.5) | 32 (16.5) | −55.8 (7.8) | 44 (22.8) | 101 (52.1) | 0.1 (0.1) |
| AC | 409 | 93 (22.9) | 267 (65.8) | 46 (11.3) | −58.1 (5.8) | 137 (34.4) | 169 (44.1) | 0.4 (0.1) | |
| CC | 225 | 42 (19.0) | 166 (75.1) | 13 (5.9) | −65.0 (7.3) | 58 (26.7) | 95 (44.6) | 0.0 (0.1) | |
| Linear Trend P§ | 0.03 | 0.40 | 0.45 | 0.14 | 0.58 | ||||
|
VEGF-A rs833069 |
CC | 103 | 21 (20.8) | 76 (75.2) | 4 (4.0) | −59.2 (10.4) | 23 (23.5) | 45 (46.4) | 0.4 (0.2) |
| TC | 359 | 71 (19.9) | 244 (68.5) | 41 (11.5) | −61.2 (6.3) | 114 (32.9) | 146 (43.3) | 0.2 (0.1) | |
| TT | 373 | 76 (20.9) | 242 (66.5) | 46 (12.6) | −57.7 (5.6) | 102 (28.1) | 174 (48.9) | 0.2 (0.1) | |
| Linear Trend P§ | 0.33 | 0.79 | 0.94 | 0.33 | 0.71 | ||||
|
VEGF-A rs833070 |
CC | 228 | 42 (18.8) | 168 (75.0) | 14 (6.3) | −63.3 (7.2) | 60 (27.4) | 94 (43.9) | 0.0 (0.1) |
| CT | 402 | 92 (23.1) | 263 (65.9) | 44 (11.0) | −60.1 (5.9) | 133 (33.9) | 169 (44.7) | 0.4 (0.1) | |
| TT | 205 | 34 (17.2) | 131 (66.2) | 33 (16.7) | −53.6 (7.6) | 46 (23.4) | 102 (51.5) | 0.1 (0.1) | |
| Linear Trend P§ | 0.043 | 0.38 | 0.42 | 0.13 | 0.63 | ||||
|
VEGF-A rs1413711 |
CC | 230 | 42 (18.6) | 170 (75.2) | 14 (6.2) | −64.5 (7.2) | 61 (27.6) | 95 (44.0) | 0.0 (0.1) |
| CT | 398 | 92 (23.3) | 259 (65.6) | 44 (11.1) | −58.7 (5.9) | 130 (33.5) | 168 (44.9) | 0.4 (0.1) | |
| TT | 207 | 34 (17.0) | 133 (66.5) | 33 (16.5) | −55.1 (7.6) | 48 (24.1) | 102 (51.0) | 0.1 (0.1) | |
| Linear Trend P§ | 0.045 | 0.38 | 0.49 | 0.16 | 0.65 | ||||
|
VEGF-A rs2010963 |
GG | 375 | 76 (20.8) | 246 (67.2) | 44 (12.0) | −58.1 (5.6) | 104 (28.5) | 173 (48.5) | 0.2 (0.1) |
| GC | 361 | 72 (20.1) | 242 (67.6) | 44 (12.3) | −60.4 (6.3) | 112 (32.1) | 149 (44.0) | 0.2 (0.1) | |
| CC | 99 | 20 (20.6) | 74 (76.3) | 3 (3.1) | −60.7 (10.7) | 23 (24.5) | 43 (45.7) | 0.4 (0.2) | |
| Linear Trend P§ | 0.39 | 0.78 | 0.92 | 0.37 | 0.72 | ||||
|
VEGFR-2 rs2071559 |
AA | 193 | 38 (20.0) | 120 (63.2) | 32 (16.8) | −60.5 (8.9) | 58 (31.0) | 87 (47.0) | 0.1 (0.1) |
| AG | 414 | 80 (19.6) | 294 (71.9) | 35 (8.6) | −51.6 (4.9) | 108 (26.7) | 195 (49.5) | 0.3 (0.1) | |
| GG | 228 | 50 (22.5) | 148 (66.7) | 24 (10.8) | −72.8 (8.2) | 73 (33.6) | 83 (39.3) | 0.3 (0.1) | |
| Linear Trend P§ | 0.13 | 0.22 | 0.50 | 0.11 | 0.37 | ||||
|
VEGF-A rs2146323 |
AA | 97 | 16 (17.4) | 58 (63.0) | 18(19.6) | −45.9 (9.2) | 23 (25.3) | 41 (44.6) | 0.1 (0.1) |
| AC | 377 | 76 (20.4) | 247 (66.2) | 50(13.4) | −55.7 (6.0) | 113 (30.6) | 179 (50.3) | 0.4 (0.1) | |
| CC | 361 | 76 (21.3) | 257 (72.2) | 23(6.5) | −66.7 (6.0) | 103 (29.6) | 145 (42.4) | 0.1 (0.1) | |
| Linear Trend P§ | 0.006 | 0.07 | 0.64 | 0.22 | 0.34 | ||||
| # of Risk Alleles | 0–6 | 31 | 9 (30.0) | 17 (56.7) | 4 (13.3) | −64.8 (22.7) | 10 (34.5) | 9 (30.0) | 0.0 (0.3) |
| 7 | 143 | 32 (22.4) | 101 (70.6) | 10 (7.0) | −79.7 (10.9) | 42 (30.2) | 67 (49.6) | 0.2 (0.1) | |
| 8 | 310 | 59 (19.5) | 210 (69.3) | 34 (11.2) | −52.7 (5.7) | 90 (30.1) | 134 (45.7) | 0.4 (0.2) | |
| 9 | 266 | 18 (21.7) | 48 (57.8) | 17 (20.5) | −54.9 (7.0) | 25 (30.5) | 120 (47.6) | 0.0 (0.2) | |
| ≥10 | 85 | 50 (19.1) | 186 (71.0) | 26 (9.9) | −60.9 (12.4) | 72 (27.8) | 35 (43.8) | 0.1 (0.1) | |
| Linear Trend P§ | 0.08 | 0.18 | 0.51 | 0.73 | 0.45 | ||||
§
The genotype is coded as 2 for two copies of risk alleles, 1 for one copy of risk allele, 0 for no risk allele.
For continuous outcome, the linear trend P value is from linear regression with the genotype as continuous variable.
For categorical outcome, the linear trend P value is from logistic regression with the genotype as continuous variable, (cumulative logit model for three level outcome).