Table 2. Correlation of C-MYC gene expression with Type I/Type II ERG ratio.
Biological Breakdown | Type I/Type II ratio | ||
---|---|---|---|
N | Median | P | |
C-MYC fold difference: | (45) | 0.37 | 0.063 |
**0.056 | |||
< 0.5 fold (down-regulation) | 8 | 0.28 | ** |
0.5-2 fold (relatively unchanged) | 23 | 0.46 | |
> 2.0 fold (up-regulation) | 14 | 0.72 |
Trending towards significance. P < 0.05 was considered significant.
As C-MYC gene expression is found to be down-regulated in CaP patients, Type I/II ERG ratio is low. When C-MYC gene expression is up-regulated in CaP patients, Type I/II ERG ratio is found to be high.