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. 2014 Jul 28;289(37):25393–25403. doi: 10.1074/jbc.M114.575894

FIGURE 8.

FIGURE 8.

Rab11b modeled to the surface of PKG Iα and PKG Iβ. A, crystal structure of PKG II LZ-Rab11b complex showing the electrostatic surface (electrostatic potential = −85 to 85) of PKG II and Rab11b represented as a ribbon diagram. B, NMR structure of PKG Iα LZ (PDB code 1ZXA) (36); C, crystal structure of PKG Iβ (PDB code 3NMD) (44) were superposed onto the PKG II LZ-Rab11b complex using the sequence alignment from Fig. 1B. Electrostatic surfaces were calculated in PyMOL revealing a charge distribution and surface contour for both PKG Iα and PKG Iβ that would be unfavorable for Rab11b interaction. Electrostatic potential range = −96 to 96 for PKG Iα and electrostatic potential range = −92 to 92 for PKG Iβ.