TABLE 1.
Rat liver toxicity panel shows little effect of PLD inhibitor VU0364739
Only globulin and total protein showed higher levels with inhibitor treatment (n = 5–6 rats per treatment; p < 0.05 by Mann-Whitney test), and both were within normal clinical ranges for both the vehicle control and PLD inhibitor treatment groups. Principal component analysis of the z-score standardized values across the screening panel displayed no clustering of the multivariate results by treatment, and none of the principal components differed significantly (p > 0.05 by t test).
| Means ± S.E. |
Units | p value | ||
|---|---|---|---|---|
| Vehicle | VU0364739 | |||
| Albumin | 3.6 ± 0.1 | 3.6 ± 0.0 | g/dl | 0.5368 |
| Alkaline phosphatase | 212 ± 11 | 207 ± 13 | units/liter | 0.7922 |
| Alanine aminotransferase | 102 ± 8 | 113 ± 5 | units/liter | 0.5368 |
| Amylase | 1118 ± 59 | 1142 ± 41 | units/liter | 0.6623 |
| Blood urea nitrogen | 12.0 ± 2.0 | 15.6 ± 1.5 | mg/dl | 0.0823 |
| Calcium | 10.8 ± 0.2 | 11.0 ± 0.2 | mg/dl | 0.3290 |
| Creatinine | 0.33 ± 0.01 | 0.42 ± 0.04 | mg/dl | 0.1255 |
| Globulin | 2.3 ± 0.1 | 2.6 ± 0.1 | g/dl | 0.0303 |
| Glucose | 143 ± 7 | 141 ± 5 | mg/dl | 0.7922 |
| Potassium | 5.72 ± 0.42 | 5.72 ± 0.15 | mmol/liter | 0.6623 |
| Sodium | 139 ± 2 | 142 ± 1 | mmol/liter | 0.3290 |
| Phosphorus | 8.8 ± 0.2 | 9.0 ± 0.2 | mg/dl | 0.5368 |
| Total bilirubin | 0.22 ± 0.07 | 0.16 ± 0.01 | mg/dl | 0.7922 |
| Total protein | 5.9 ± 0.1 | 6.3 ± 0.1 | g/dl | 0.0303 |