FIGURE 12.

Ovariectomy does not prevent intramedullary bone in the tibia of female Prkca^−/− mice. Female Prkca^−/− mice (n = 7) and WT controls (n = 5) were subjected to ovariectomy (OVX) at 8 weeks of age and sacrificed 10 weeks later. Their left limbs were compared with the left limbs of non-ovariectomized controls. A, representative cross-sectional images are shown. Medullary area (Ma.Ar; B), total tissue area (Tt.Ar; C), and cortical area (Ct.Ar; D) were determined by μCT 50% of the tibia's length from the proximal end. Bars, mean percentage change ± S.E. (error bars). *, p < 0.05; **, p < 0.01, indicating the effect of OVX. #, p < 0.05; ##, p < 0.01 versus similarly treated WT mice.