TABLE 3.
A number of differentially abundant proteins were identified by ProgenesisTM LC-MS software between young and old tendon. All proteins with a >2-fold change in normalized abundance are shown
A value of infinity is given when no peptides for a given protein in the group other than the highest mean condition were identified.
| Highest mean condition | Accession | Description | Role | Peptide count | Max -fold change | ANOVA |
|---|---|---|---|---|---|---|
| p | ||||||
| Young | XP_001503038.3 | Protein disulfide-isomerase A3 isoform 1 | ER enzyme-protein folding | 2 | Infinity | 0.003 |
| XP_001491653.1 | Asporin isoform 1 | SLRP-collagen interaction | 2 | 264.2 | 0.03 | |
| XP_001916358.2 | Neuroblast differentiation-associated protein AHNAK | Cell proliferation/differentiation | 3 | 83.6 | 0.027 | |
| XP_001497470.1 | Histone H2B type 1-M isoform 1 | DNA packaging protein | 10 | 54.8 | 0.002 | |
| XP_001500135.1 | Histone H2B type 2-F | DNA packaging protein | 10 | 54.5 | 0.006 | |
| XP_001918010.1 | Mimecan | SLRP-collagen interaction | 4 | 29.4 | 0.002 | |
| NP_001075246.1 | Fibromodulin | SLRP-collagen interaction | 14 | 21 | 0.008 | |
| XP_001504528.1 | Heat shock protein β-1 | Antiapoptotic and anti-inflammatory | 2 | 10.5 | 0.003 | |
| XP_001915599.1 | UPF0293 protein C16orf42 | Unknown | 1 | Infinity | 0.031 | |
| XP_001493624.2 | ras-related C3 botulinum toxin substrate 1 | Cell growth, cytoskeletal organization | 1 | Infinity | 0.004 | |
| XP_001490052.2 | Integrin β-2 | Cell attachment | 1 | Infinity | 0.003 | |
| XP_001500627.1 | Spectrin α chain, brain isoform 1 | Cytoskeletal protein | 1 | Infinity | 0.001 | |
| XP_001496993.1 | Peptidyl-prolyl cis-trans isomerase A isoform 1 | Enzyme-protein folding | 1 | 666.2 | 0.009 | |
| Old | XP_001504448.1 | Keratin, type II cytoskeletal 75 isoform 1 | Intermediate filament protein | 11 | Infinity | 0.001 |
| XP_001497733.1 | Keratin, type I cuticular Ha5 | Intermediate filament protein | 5 | Infinity | 0.001 | |
| XP_001504468.1 | Keratin, type II cytoskeletal 5 isoform 1 | Intermediate filament protein | 14 | 20 | 0.027 | |
| XP_001504484.1 | Keratin, type II cytoskeletal 73 isoform 1 | Intermediate filament protein | 8 | 16.6 | 0.047 | |
| XP_001917840.1 | Junction plakoglobin | Cell junction protein | 2 | 9.9 | 0.049 | |
| XP_001499854.1 | Keratin, type I cytoskeletal 10 | Intermediate filament protein | 24 | 8.9 | 0.012 | |
| XP_001496987.1 | Keratin, type I cytoskeletal 14 | Intermediate filament protein | 10 | 8.9 | 0.006 | |
| XP_001489373.1 | Major allergen Equ c 1 | Transporter protein | 2 | 8.5 | 0.003 | |
| XP_001504488.2 | Keratin, type II cytoskeletal 2 epidermal | Intermediate filament protein | 11 | 7.3 | 0.026 | |
| XP_001494629.3 | Keratin, type II cytoskeletal 1 | Intermediate filament protein | 12 | 6.3 | 0.032 | |
| XP_001494427.2 | Keratin, type II cuticular Hb5 | Intermediate filament protein | 12 | 4 | 0.029 | |
| XP_001504460.2 | keratin, type II cytoskeletal 6B | Intermediate filament protein | 14 | 3.6 | 0.016 | |
| XP_001916241.2 | Desmoglein-1 | Cell junction protein | 2 | 2.1 | 0.012 | |
| XP_001916548.2 | Desmoplakin | Cell junction protein | 1 | Infinity | 0 | |
| NP_001093583.1 | Secretory phospholipase A2 | Lipid metabolism | 1 | 7091.7 | 0.009 | |
| NP_001075966.1 | Major allergen Equ c 1 precursor | Transporter protein | 1 | 779.5 | 0.001 | |
| XP_001502526.1 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Vesicular transport | 1 | 5.6 | 0.005 |