TABLE 4.
A number of differentially abundant proteins were identified by ProgenesisTM LC-MS software between diseased young and old tendon
All proteins with a >2-fold change in normalized abundance are shown. All proteins were at higher levels in the young diseased tendon.
| Accession | Description | Role | Peptide count | Max fold change | ANOVA (p) |
|---|---|---|---|---|---|
| XP_001490861.2 | Cofilin-2 | Actin disassembly | 2 | 631.4 | 0.003 |
| XP_001493508.1 | Tenascin-N | Facilitates neural growtha | 4 | 18.2 | 0.019 |
| XP_001501829.1 | α-Crystallin B chain | Increase cell tolerance to stressa,b | 8 | 12.7 | 0.004 |
| XP_001503950.1 | Tubulointerstitial nephritis antigen 1 isoform 1 | Cysteine peptidase-ECM turnover | 2 | 7.4 | 0.004 |
| NP_001075421.1 | α-Fetoprotein precursor | Plasma proteina | 1 | 5.1 | 0.017 |
| XP_001503085.1 | Actin, aortic smooth muscle isoform 1 | Cell motility | 20 | 5.1 | 0.015 |
| XP_001915023.1 | Cysteine-rich protein 2 | Inhibits inflammatory pain | 1 | 5.0 | 0.009 |
| XP_001917554.1 | Procollagen C-endopeptidase enhancer 2 | Enhances cleavage of pro-collagena,b | 3 | 4.4 | 0.003 |
| XP_003363861.1 | Heat shock 70-kDa protein 1 | Protects cells from thermal stress | 4 | 4.2 | 0.004 |
| XP_001503538.2 | Target of Nesh-SH3 isoform 4 | ECM organisation | 1 | 3.3 | 0.001 |
| XP_001916170.2 | protein SZT2 | Involved in oxidative stress | 5 | 3.2 | 0.020 |
| XP_001915664.2 | Microfibrillar-associated protein 5 | Associates with elastic fibres, stabilizes procollagen | 2 | 3.1 | 0.050 |
| XP_001494523.1 | Polymerase I and transcript release factor isoform | Transcription regulation | 9 | 3.0 | 0.029 |
| XP_001916600.1 | Insulin growth factor binding protein-6 | Carrier protein for IGF-1 | 3 | 3.0 | 0.033 |
| NP_001229384.1 | SH3 domain binding glutamic acid-rich protein like 3 | Nuclear/cytoplasmic protein | 3 | 2.9 | 0.004 |
| XP_001503725.1 | Annexin A6 | Regulation of membrane traffic | 4 | 2.8 | 0.025 |
| XP_001498580.3 | Integrin α-V | Cell-cell & cell-matrix interactionsa | 3 | 2.6 | 0.009 |
| XP_001914753.2 | Catalase | Prevents cells from oxidative damage | 22 | 2.5 | 0.007 |
| XP_001914918.2 | Fibulin-2 | Interacts with elastic fibres | 13 | 2.3 | 0.030 |
| XP_001504528.1 | Heat shock protein β1 | Protects cells from thermal stress | 7 | 2.2 | 0.043 |
| XP_001916279.2 | ATP synthase subunit α, mitochondrial | ATP synthesis | 4 | 2.1 | 0.032 |
| XP_001496987.1 | Keratin, type I cytoskeletal 14 | Intermediate filament proteina | 3 | 2.0 | 0.002 |