Fig 4.

Modular allostery by inhibitory gate domain to prevent DNA binding to Snf2 ATPase. (A) S. cerevisiae Chd1 ATPase region with equivalent orientation and colouring to Rad54 in fig 3A. Chromowedge domain (yellow) at rear. (B) View from A rotated 120° to illustrate Chromowedge domain association with protrusion 2 and RecA lobe 2. (C) Schematic of modulation by switching of ‘gate’ domain (yellow) on Snf2 ATPase through introduction of an alternative binding site (light grey). (D) Modulation by competition with ‘gate’ domain (yellow) through introduction of a competitor for Snf2 ATPase binding (dark grey). Structure PDB code 3MWY [39].