Table 2.
Nomenclature of Snf2 family members in S. cerevisiae and Human
| Snf2 subfamily | Grouping | S. cerevisiae genes | S. cerevisiae nomenclature | Human genes | Human nomenclature |
|---|---|---|---|---|---|
| Snf2 | Snf2-like | SNF2, STH1 | Sucrose Non Fermenting, Snf Two Homolog | SMARCA4/BR G1, SMARCA2/hB RM | Brm-Related Gene, human BRahMa-like |
| Iswi | Snf2-like | ISW1, ISW2 | Imitation SWitch | SMARCA1/SN F2L, SMARCA5/hS NF2H | SNF2-Like, human SNF2 Homologue |
| Lsh | Snf2-like | IRC5 | Increased Recombination Centres | HELLS/SMAR CA6 | HELicase, Lymphoid-Specific |
| ALC1 | Snf2-like | - | ALC1 | Amplified in Liver Cancer | |
| Chd1 | Snf2-like | Chd1 | Chromo Domain containing | CHD1L | CHD1-Like |
| Mi-2 | Snf2-like | - | CHD3, CHD4, CHD5 | CHD1-like | |
| CHD7 | Snf2-like | - | CHD6, CHD7, CHD8, CHD9 | Chd1-like | |
| Swr1 | Swr1-like | SWR1 | ? | SRCAP | Snf2-related CREBBP activator protein |
| EP400 | Swr1-like | - | EP400 | E1A binding protein p400 | |
| Ino80 | Swr1-like | INO80 | INOsitol biosynthesis | INO80 | INO80 homolog |
| Etl1 | Swr1-like | FUN30 | Function UNknown | SMARCAD1 | SMARCA containing DEAD/H box |
| Rad54 | Rad54-like | RAD54 | RADiation sensitive | RAD54L, RAD54B | RAD54-Like, RAD54 homologue B |
| ATRX | Rad54-like | - | ATRX | Alpha Thalassemia/mental Retardation syndrome X-linked | |
| Arip4 | Rad54-like | - | RAD54L2 | RAD54-Like 2 | |
| Rad5/16 | Rad5/16-like | Rad5, Rad16 | RADiation sensitive | HLTF/SMARC A3 | Helicase-Like Transcription Factor |
| Ris1 | Rad5/16-like | ULS1 | Ubiquitin Ligase for SUMO conjugates | - | |
| Lodestar | Rad5/16-like | - | TTF2 | Transcription Termination Factor, RNA polymerase II | |
| SHPRH | Rad5/16-like | IRC20 | Increased Recombination Centres | SHPRH | SNF2 Histone linker PHD RING Helicase |
| Mot1 | Sso1653-like | MOT1 | Modifier Of Transcription | BTAF1 | B-TFIID Transcription Associated Factor |
| ERCC6 | Sso1653-like | RAD26 | RADiation sensitive | ERCC6, ERCC6L, C9orf102 | Excision Repair Cross-Complementing rodent repair deficiency, complementation group 6, chromosome 9 open reading frame 102 |
| SMARCAL1 | Smarcal1-like | - | SMARCAL1, ZRANB3 | SMARCA Like, Zinc finger, RAN-Binding domain containing 3 |
Nomenclature of Snf2-related proteins using subfamily and grouping classifications from [26] based on alignments of the helicase-like region. Subfamilies are named from the first reported archetype in any organism. S. cerevisiae nomenclature is from Saccharomyces Genome Database and human nomenclature is from ENSEMBL using official Human Genome Naming Commission symbols. Some members are known by a SMARCA acronym standing for for “SWI/SNF-related, Matrix-associated, Actin-dependent Regulator Chromatin group A”. Where common alternatives are used alongside SMARCA nomenclature, the official HGNC name is shown first.