(A) Z maps of the grand means (i.e., across all 763 individuals) and
(B) of the group differences between individuals with Autism
Spectrum Disorders (ASD) and Typical Controls (TC) for the two midline core seed
regions located in Posterior Cingulate Cortex (PCC) and Anterior Medial
Prefrontal Cortex (aMPFC). Seeds were centered at Montreal Neurological
Institute stereotaxic coordinates x=−8, y=−56,
z=26 for PCC and x=−6, y=52,
z=−2 for aMPFC, and are depicted as white dots on the surface
maps. Gaussian random field theory was used to carry out cluster-level
corrections for multiple comparisons (voxel-level Z>2.3; cluster
significance: p<0.05, corrected). Significant clusters are overlaid on
inflated surface maps generated using BrainNet Viewer (http://www.nitrc.org/projects/bnv/), as well as on axial images
generated with REST Slice Viewer (http://www.restfmri.net).
L= Left hemisphere; R= Right hemisphere.