Table 1.
Segment characteristics on CTA according to segment-level diagnostic concordance between CTA and QCA for (a) all studied segments; (b) segments with obstructive CAD on QCA; and (c) segments without obstructive CAD on QCA
| (a) All segments | (b) Segments with obstructive CAD on QCA | (c) Segments without obstructive CAD on QCA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Diagnostic Concordance (CTA- Accuracy) (TP and TN) (N=748) | Diagnostic Discordance (CTA- Inaccuracy/Misdiagnosis) (FP and FN) (N=274) | P- value* | Diagnostic Concordance (CTA- Accuracy) (TP) (N=237) | Diagnostic Discordance (CTA- Inaccuracy) (FN) (N=159) | P- value* | Diagnostic Concordance (CTA- Accuracy) (TN) (N=511) | Diagnostic Discordance (CTA- Inaccuracy) (FP) (N=115) | P- value* | |
| Segment location | |||||||||
| Left-main artery† | 31(4.1) | 3(1.1) | 0.017 | 2(0.8) | 1(0.6) | 0.81 | 29(5.7) | 2(1.7) | 0.081 |
| LAD† | 187(25.0) | 71(25.9) | 0.77 | 85(35.9) | 30(18.9) | <0.001 | 102(20.0) | 41(35.7) | 0.001 |
| Diagonal branches† | 70(9.4) | 46(16.8) | 0.001 | 19(8.0) | 32(20.1) | 0.001 | 51(10.0) | 14(12.2) | 0.48 |
| RCA† | 145(19.4) | 52(19.0) | 0.89 | 55(23.2) | 31(19.5) | 0.43 | 90(17.6) | 21(18.3) | 0.88 |
| PDA/PLV† | 82(11.0) | 19(6.9) | 0.081 | 9(3.8) | 14(8.8) | 0.76 | 73(14.3) | 5(4.3) | 0.004 |
| LCx† | 109(14.6) | 29(10.6) | 0.11 | 25(10.5) | 9(5.7) | 0.10 | 84(16.4) | 20(17.4) | 0.80 |
| OM/Ramus-intermedius/Left-PLV† | 124(16.6) | 54(19.7) | 0.22 | 42(17.7) | 42(26.4) | 0.038 | 82(16.0) | 12(10.4) | 0.102 |
| Tomographic segment characteristics | |||||||||
| Segment tortuosity† | 111(14.9) | 102(37.5) | <0.001 | 53(22.6) | 66(41.8) | <0.001 | 58(11.4) | 36(31.6) | <0.001 |
| Vein crossing† | 127(17.0) | 79(29.0) | <0.001 | 41(17.4) | 48(30.4) | 0.003 | 86(16.9) | 31(27.2) | 0.005 |
| Motion artifact-related suboptimal segment image quality† | 445(59.5) | 207(75.5) | <0.001 | 157(66.2) | 129(81.1) | 0.001 | 288(56.4) | 78(67.8) | 0.027 |
| Presence of segmental coronary calcification† | 294(39.8) | 164(61.2) | <0.001 | 168(72.4) | 79(51.0) | <0.001 | 126(24.9) | 85(75.2) | <0.001 |
| Segment diameter‡ (mm) | 2.71±0.04 | 2.33±0.04 | <0.001 | 2.66±0.05 | 2.21±0.05 | <0.001 | 2.72±0.04 | 2.50±0.06 | 0.002 |
| Mean segment luminal opacification‡(HU) | 441±8 | 424±10 | 0.093 | 459±10 | 400±12 | <0.001 | 433±9 | 457±12 | 0.078 |
CAD=coronary artery disease, QCA=quantitative coronary angiography; CTA= computed tomography angiography; TP=true-positive; TN=true-negative; FP=false-positive; FN=false-negative, LAD=left anterior descending artery, RCA= right coronary artery, LCx=left circumflex coronary artery, PDA=posterior descending artery, PLV=posterolateral branches, OM=obtuse marginal branches.
*
Unadjusted complex sample analysis accounted for within-patients clustering;
†
counts(%);
‡
mean ± standard error.