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Lafora bodies in Epm2a−/− and Epm2b−/− mice brains. Citoplasmic polyglucosan inclusions (arrows) positive for periodic acid-Shiff staining (PAS) (A,B) in layer V of the cerebral cortex, and immunostained for ubiquitin (C,D) in Layer IV (C) and IV-V (D) of cerebral cortex of Epm2a−/− (A,C) and Epm2b−/− (B,D) mice at 17 months of age. Scale bar = 20 μm.
