Figure 2.

Increased sensitivity of Epm2a^−/− and Epm2b^−/− models to the chemoconvulsant agent PTZ. Two different age groups (4–8 and 9–23 months) of control, Epm2a^−/−, and Epm2b^−/− mice were injected intraperitoneally with 30 (A,C) and 50 mg/kg of PTZ (B,D) and the percentages of mice showing PTZ-induced myoclonus (A,B), and generalized seizures (C,D) were recorded ^*p < 0.05; ^**p < 0.01; ^***p < 0.001, Chi-square (n = 16–36 mice per group at each PTZ dose).