Figure 3.

Analysis of seizure latency and length of PTZ-induced generalized seizures in Epm2a^−/− and Epm2b^−/− mice. Mice within 2 different age spans (4–8 and 9–23 months) were injected with a convulsive dose of PTZ (50 mg/kg). (A) The time interval between drug administration and development of generalized tonic-clonic seizures and (B) the seizure length were measured. Data are presented as mean ± s.e.m. Student's t-test was performed for statistical evaluation. ^*p < 0.05 (n = 12–25).