Table 1.
Schema of dual-resistance model
Primary Treatment Group (4 drugs)+ | Secondary Treatment group (9 drugs)++ | ||||
---|---|---|---|---|---|
Platinum | Taxane | Gemcitabine | Topotecan | Doxil | |
Dual-resistance | EDR | LDR | EDR | IDR | LDR |
Non-resistance | IDR | LDR | IDR | IDR | LDR |
Dual-resistance was defined as the presence of EDR in both groups. Non-resistance was defined as absence of EDR in both groups.
First group included cisplatin, carboplatin, paclitaxel, and docetaxel.
Second group included cyclophosphamide, doxil, doxorubicin, etoposide, fluorouracil, gemcitabine, gemcitabin with cisplatin, ifosamide, and topotecan (schematically 2 and 3 drugs are shown in each group, respectively).
Abbreviations: EDR, extreme drug resistance; IDR, intermediate drug resistance; and LDR, low drug resistance.