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. 2014 Oct 1;24(5):356–363. doi: 10.1089/nat.2014.0486

FIG. 1.

FIG. 1.

Artificial microRNA–truncated CD34 (amiR–tCD34) vector design. Shown in the top diagram is the design principle for amiRs, which contain the 5′, loop, and 3′ sequences from a primary microRNA (miR) transcript with the stem sequence being derived from a small interfering RNA (siRNA). The MSGV2–tCD34 vector is shown in the bottom diagram with the location of the insertion sites for the amiR sequences. LTR, long terminal repeat; SD, splice donor; ψ+, extended packaging sequence; SA, splice acceptor.