Table 2.

Multivariate Cox proportional hazard analysis for prediction of recurrence in non muscle invasive bladder cancer (n=178).

Variable	HR (95% confidence interval)	P
CDH13 methylation (M vs. U)	5.147 (2.071–20.177)	0.0043
Age (>65 vs. ≤65)	1.013 (0.725–5.051)	0.8642
Sex (male vs. female)	1.525 (0.667–4.946)	0.7136
Number (multiple vs. single)	1.786 (0.837–10.418)	0.7005
Size (>3 cm vs. ≤3 cm)	3.504 (0.796–11.587)	0.5486
Grade (G2/G3 vs. G1)	3.713 (0.917–11.028)	0.0894
Stage (T1 vs. Ta)	4.963 (2.567–14.622)	0.0265

HR – hazard ratio; M – methylated; U – unmethylated.