Table 3.

Multivariate Cox proportional hazard analysis for prediction of progression in non muscle invasive bladder cancer (n=178).

Variable	HR (95% confidence interval)	P
CDH13 methylation (M vs. U)	6.563 (2.241–21.707)	0.0016
Age (>65 vs. ≤65)	1.133 (0.705–6.017)	0.6412
Sex (male vs. female)	1.125 (0.568–4.136)	0.7003
Number (multiple vs. single)	1.868 (0.737–10.418)	0.4713
Size (>3 cm vs. ≤3 cm)	2.004 (0.754–10.417)	0.2481
Grade (G2/G3 vs. G1)	2.881 (0.837–13.213)	0.0796
Stage (T1 vs. Ta)	4.037 (1.968–17.542)	0.0185

HR – hazard ratio; M – methylated; U – unmethylated.