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. 1971 Jun;3(6):833–837. doi: 10.1128/iai.3.6.833-837.1971

Pathogenesis of Feline Panleukopenia Virus in Susceptible Newborn Kittens I. Clinical Signs, Hematology, Serology, and Virology 1

C K Csiza a,2, F W Scott a, A De Lahunta a, J H Gillespie a
PMCID: PMC416246  PMID: 16558063

Abstract

Inoculation of susceptible newborn kittens with a large dose of panleukopenia virus caused subclinical infection in 19 of 23 cases. All infected kittens developed severe and prolonged leukopenia. Cell-free virus was present in the blood from 1 to 7 postinoculation days. The virus spread to all organs, regardless of the route of inoculation. The thymus, spleen, mesenteric lymph nodes, and the cerebellum were the most severely infected organs. Kittens responded to virus infection by production of specific antibodies, first detectable in the circulatory system 6 to 8 days after infection. Antibody production preceded recovery from leukopenia by 3 days.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Csiza C. K., Scott F. W., de Lahunta A., Gillespie J. H. Immune carrier state of feline panleukopenia virus-infected cats. Am J Vet Res. 1971 Mar;32(3):419–426. [PubMed] [Google Scholar]
  2. Johnson R. H. Feline panleucopaenia. I. Identification of a virus associated with the syndrome. Res Vet Sci. 1965 Oct;6(4):466–471. [PubMed] [Google Scholar]
  3. Johnson R. H., Margolis G., Kilham L. Identity of feline ataxia virus with feline panleucopenia virus. Nature. 1967 Apr 8;214(5084):175–177. doi: 10.1038/214175a0. [DOI] [PubMed] [Google Scholar]
  4. Kilham L., Margolis G. Viral etiology of spontaneous ataxia of cats. Am J Pathol. 1966 Jun;48(6):991–1011. [PMC free article] [PubMed] [Google Scholar]
  5. Lust S. J., Gorham J. R., Sato N. Occurrence of intranuclear inclusions in cell cultures infected with infectious feline enteritis virus. Am J Vet Res. 1965 Sep;26(114):1163–1166. [PubMed] [Google Scholar]
  6. Macpherson L. W. Feline Enteritis Virus - Its Transmission To Mink Under Natural And Experimental Conditions. Can J Comp Med Vet Sci. 1956 Jun;20(6):197–202. [PMC free article] [PubMed] [Google Scholar]
  7. Scott F. W., Csiza C. K., Gillespie J. H. Feline viruses. V. Serum-neutralization test for feline panleukopenia. Cornell Vet. 1970 Apr;60(2):183–191. [PubMed] [Google Scholar]
  8. Wills C. G. Notes on Infectious Enteritis of Mink and its Relationship to Feline Enteritis. Can J Comp Med Vet Sci. 1952 Dec;16(12):419–420. [PMC free article] [PubMed] [Google Scholar]

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