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. 2014 Sep 3;3:571. doi: 10.1038/bonekey.2014.66

Figure 2.

Figure 2

Localisation of SOST mRNA and protein in the SFx region. (a) SOST mRNA (ai) and sclerostin protein (bi) localised in osteocytes (arrows) adjacent to the SFx line. (bii) Shows sclerostin labelling at a site distant to the SFx line in the same section. Both anti-sense probe and isotype control were negative (aii, biii). (c) Labelling indices (L.Ot.N/Ot.N, %) of sclerostin protein were significantly reduced in the fracture region when compared with the ULC across all time-points (c, P<0.001). SFx, stress fracture. ULC, unloaded control. **P<0.001, Scale bar, 50 μm.