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Inactivation and reactivation rates of PTEN and PTP1B upon oxidation with H2O2 and reduction with either DTT, GSH, TRX1/TR or GRX/GSH
| Enzyme | H2O2 (M−1s−1) |
DTT (M−1s−1) |
GSH (M−1s−1) |
TRX1/TR (M−1s−1) |
GRX/GSH (M−1s−1) |
|---|---|---|---|---|---|
| PTEN | 14± 0.5 | 0.83± 0.12 | 0.036± 0.01 | 0.95± 0.15 | 0.14± 0.04 |
| PTP1B | 10± 0.8 | 0.55± 0.1 | 0.042± 0.01 | 0.75± 0.2 | 0.12± 0.03 |
