Table 3.

Change from baseline to week 8 in composite z-score and DSST (number of correct symbols) – depression mediator: change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score

Variable	Vortioxetine 10 mg	Vortioxetine 20 mg
	Difference to placebo at week 8 (FAS, LOCF)
All patients	n = 193	n = 204
Effect on composite z-score after correcting for effect on MADRS	0.23***	0.15*
Effect on DSST after correction for effect on MADRS	2.59**	2.23**
	Direct treatment effect: % (95% CI) (FAS, LOCF)
Composite z-score	64 (47; 82)	48 (23; 73)
DSSTcorrect symbols	66 (47; 84)	56 (34; 78)
	Difference to placebo at week 8 (FAS, MMRM)
Non-responders§	n = 92	n = 68
Composite z-score	0.20*	0.28**
DSSTcorrect symbols	2.25*	2.88**
Non-remitters (MADRS > 10)	n = 123	n = 110
Composite z-score	0.26**	0.28**
DSSTcorrect symbols	3.05**	3.53***

^*p < 0.05, **p < 0.01, ***p < 0.001 vs. placebo.

^§<50% reduction from baseline to week 8 in MADRS total score.