Table 2.
Multivariable analysis of KLK2 SNPs and hK2 levels in predicting the presence of prostate cancer at the time of repeat biopsy
| Subgroup | Odds Ratio | 95% CI | P | |
|---|---|---|---|---|
| Age | 1.35 | 1.02 - 1.79 | 0.049 | |
| PSA (ng/mL) | 1.41 | 1.02 - 1.96 | 0.092 | |
| DRE | 1.20 | 0.80 - 1.80 | 0.372 | |
| Presence of LUTS | 0.80 | 0.56 – 1.13 | 0.205 | |
| TRUS volume (cc) | 0.33 | 0.24 - 0.45 | < 0.0001 | |
| Family history | 1.40 | 0.86 - 2.28 | 0.175 | |
| Ethnic background | Other + Asian | 1.00 | 0.006 | |
| White | 2.30 | 1.15 - 4.62 | ||
| Black | 4.01 | 1.70 - 9.45 | ||
| Initial Biopsy Pathology | BPH or Normal | 1.00 | ||
| HGPIN | 1.79 | 1.22 - 2.62 | 0.0002 | |
| ASAP | 2.62 | 1.51 - 4.54 | ||
| rs2664155 (KL1) | GG vs. GA | 1.47 | 0.84 - 2.57 | 0.218 |
| GG vs. AA | 1.14 | 0.78 - 1.69 | ||
| rs198977 (KL2) | TT vs. CT | 1.23 | 0.72 – 2.09 | 0.049 |
| TT vs. CC | 1.81 | 1.04 – 3.13 | ||
| hK2 Level (ng/mL) | 2.03 | 1.4 – 2.99 | 0.002 |