Table 4. EGFR mutation detectability of various mutant type-specific sensitive methods in an independent cohort analyzed by direct sequencing (a total of 996 patients, of whom 598 harbored EGFR mutations).
| MS | ARMS | Cobas | |
| Detectability, n | |||
| Fully detectablea | 525 | 519 | 513 |
| Partly detectableb | 30 | 36 | 36 |
| Undetectable | 43 | 43 | 49 |
| Detection rate, (%) | 92.8 (555/598) | 92.8 (555/598) | 91.8 (549/598) |
| (Fully + Partly detectable) | |||
| Accuracy rate (%) | 87.8 (525/598) | 86.8 (519/598) | 85.8 (513/598) |
| (Fully detectable) |
EGFR, epidermal growth factor receptor; MS, matrix-assisted laser desorption ionization-time of flight mass spectrometry; ARMS, Scorpions amplification refractory mutation system.
a
Fully detectable: full spectrum of mutation(s) could be detected correctly.
b
Partly detectable: part of complex mutations could be detected.