Table 1. Demographic data of patient-derived cell lines.
Cell line | Pathologic diagnosis | Age* | Gender | Smoking (pk-yrs) | FVC (% pred)* | DLCO (% pred)* | TLC (% pred)* | Honeycomb on CT |
Nonfibrotic controls | ||||||||
NF-1 | Hamartoma | 59 | M | 10 | 119 | 102 | NA | No |
NF-2 | Lung CA | 58 | M | 50 | 98 | NA | NA | No |
NF-3 | Lung CA | 53 | M | 20 | 88 | NA | NA | No |
Commercial nonfibrotic cell lines | ||||||||
CCL190 | Nml lung, died of sarcoma | 18 | M | |||||
CCL204 | Nml lung, died of astrocytoma | 35 | M | |||||
CCL210 | Nml lung, died of head trauma | 20 | F | |||||
IPF | ||||||||
IPF-1 | UIP | 65 | F | 67.5 | 72 | 57 | 73 | No |
IPF-2 | UIP | 44 | F | 0 | 52 | 39 | 57 | No |
IPF-3 | UIP | 67 | F | 20 | 62 | 37 | 71 | Yes |
IPF-4 | UIP | 46 | F | NA | 39 | 29 | 49 | No |
IPF-5 | UIP | 70 | M | 25 | 48 | 35 | 56 | No |
IPF-6 | UIP | Not available; de-identified lung from IPF patient obtained at time of transplant |
*prior to biopsy; DLCO (diffusing capacity for carbon monoxide); TLC (total lung capacity); FVC (forced vital capacity).