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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Hypertension. 2014 Jul 7;64(4):852–859. doi: 10.1161/HYPERTENSIONAHA.114.03848

Figure 2. Maternal plasma copeptin concentration is significantly predictive of the development of preeclampsia in all three trimesters of pregnancy.

Figure 2

Receiver operating characteristic (ROC) curves illustrate performance of maternal plasma copeptin in each trimester to identify pregnancies that will eventually develop preeclampsia (area under the curve, AUC). Trimester-specific cutoffs were calculated to maximize the true positive rate (sensitivity), while minimizing the false positive rate (1-specificity). AUC values from all three trimesters are statistically significant at p<0.0001 (A and B). Furthermore, first trimester maternal plasma copeptin concentrations exhibit clinically significant positive and negative predictive values (C).