TABLE 1.
Baseline | Final at 4 weeks | ||||
---|---|---|---|---|---|
Group (n) | Body weight (g) |
Systolic BP mmHg |
Proteinuria mg/24h |
Body weight (g) |
Proteinuria mg/24h |
1% NaCl (27) | 244 ± 4.7 | 171.5 ± 1.8 | 7.3 ± 0.8 | 261 ± 6.7 | 115.5 ± 12.8 |
1% NaCl (15) + enalapril | 262 ± 5.4 | 176.2 ± 2.2 | 5.6 ± 0.4 | 301* ± 2.7 | 24.3* ± 3.1 |
1% NaCl (15) + H&H | 249 ± 4.6 | 173.6 ± 2.1 | 6.8 ± 0.7 | 295* ± 5.0 | 14.1* ± 0.9 |
1% NaCl (13) + amlodipine | 247 ± 6.1 | 175.3 ± 2.1 | 6.2 ± 0.6 | 282 ± 6.2 | 22.2* ± 2.4 |
Footnote: H&H – a combined antihypertensive regimen of hydralazine and hydrochlorothiazide
p < 0.05 vs. the untreated 1% NaCl only group. The final data at 4 weeks for the untreated 1% NaCl groups includes data obtained from 6 rats before the 4 weeks who were euthanized for humane reasons between the 3rd and 4th week.