TABLE 2.

Quantitation and distribution of histologic hypertensive injury

Group (n)	Vascular Injury	% Glomerular Injury		Total HIRD Score
	Score	sclerosis/necrosis	Ischemia
1% NaCl (27)	15.5±2.2	4.4±0.8	11.9±2.3	35.9±4.9
1% NaCl (15) + Enalapril	2.0±0.7*	0.3±0.2*	3.3±1.4*	5.6±2.3*
1% NaCl (15) + H&H	0.1±0.1*	0.1±0.1*	0.1±0.1*	0.6*
1% NaCl (13) + Amlodipine	0*	0*	0.2±0.2*	0.6±0.2*

Histologic renal damage was quantitated in a blinded fashion in perfusion fixed kidneys of untreated salt supplemented SHRsp and those which additionally received enalapril, a combination of hydralazine and hydrochlorothiazide (H&H) or amlodipine (see Methods for details).

^*p<0.05 maximum vs. the untreated 1% NaCl only group.