Fig. 2.

Roles of phospholipids in mitochondrial division, fusion and degradation. During mitochondrial division, phospholipids help assemble Dnm1/Drp1 on the surface of mitochondria together with its receptor proteins. Upon stress, CL is externalized to the outer membrane and can promote mitophagy and apoptosis. During mitochondrial fusion, dynamin-related GTPases and phospholipids work together. While Fzo1/mitofusin along with PA and LPA mediate outer membrane fusion, Mgm1/Opa1, CL and PE control inner membrane fusion