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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Hypertension. 2014 Jun 23;64(4):777–783. doi: 10.1161/HYPERTENSIONAHA.114.03188

Figure 3. Increased AT2R expression in the NTS/DMV restores baroreflex function and decreases the higher LF of SBP in 2K1C rats.

Figure 3

Normotensive (NT) or 2K1C rats received intra-NTS injections of AAV2-CBA-eGFP or AAV2-CBA-AT2R followed by measurement of MAP, analysis of the SBP variability and baroreflex function as detailed in the Methods. (A) Increased AT2R expression in the NTS/DMV decreases mean arterial pressure in 2K1C rats but not in NT rats. (B) Baroreflex function curves from 2K1C and NT rats. Grouped HR baroreflex slopes in response to each 10 mmHg change in MAP produced by phenylephrine (pressor) or SNP (depressor) as described in the Methods. (C) Power of SBP spectra at the low frequency band (LF). Results in panels A and C are presented as mean ± SEM; NT-eGFP, n = 8; NT-AT2R, n = 9; 2K1C-eGFP, n = 9; 2K1C-AT2R, n = 9. *p< 0.05 vs. respective treatment in NT rats; #p<0.05 vs. 2K1C-eGFP; &p<0.05 vs. all groups.