Table 2.
Clinical performance of DC and cytology, with combined histopathology result as the reference standard
| CIN2+ threshold on histopathology | ||||||||
|---|---|---|---|---|---|---|---|---|
| True + | False + | True − | False − | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | |
| DC positive | 51 | 102 | 140 | 10 | 84% (72–91) | 58% (52–64) | 33% (26–41) | 93% (88–96) |
| HSIL+ | 37 | 101 | 141 | 24 | 61% (48–72) | 58% (52–64) | 27% (20–35) | 86% (79–90) |
| LSIL+ | 55 | 157 | 85 | 6 | 90% (80–95) | 35% (29–41) | 26% (21–32) | 93% (86–97) |
| ASC-US+ | 61 | 210 | 32 | 0 | 100% (94–100) | 13% (10–18) | 23% (18–28) | 100% (89–100) |
| CIN3+ threshold on histopathology | ||||||||
|---|---|---|---|---|---|---|---|---|
| True + | False + | True − | False − | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | |
| DC positive | 28 | 125 | 145 | 5 | 85% (69–93) | 54% (48–60) | 18% (13–25) | 97% (92–99) |
| HSIL+ | 21 | 117 | 153 | 12 | 64% (47–78) | 57% (51–62) | 15% (10–22) | 93% (88–96) |
| LSIL+ | 32 | 180 | 90 | 1 | 97% (85–100) | 33% (28–39) | 15% (11–21) | 99% (94–100) |
| ASC-US+ | 33 | 238 | 32 | 0 | 100% (90–100) | 12% (9–16) | 12% (9–17) | 100% (89–100) |
CIN, cervical intraepithelial neoplasia; CI, confidence interval; DC, digital cervicography; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; ASC-US, atypical squamous cells of uncertain significance.
A “+” denotes “or greater;” e.g., CIN2+ denotes a biopsy result of CIN2 or greater.