Table 2.
Hazard ratios for total mortality according to quartiles and per SD of FFA and FABP4 in Cardiovascular Health Study
| Number of Events | Model 1 | Model 2 | |||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||
| FFA Q1 (Reference) | 3555 | 1.00 | 1.00 | ||
| FFA Q2 | 1.02 | (0.93–1.12) | 1.05 | (0.95–1.15) | |
| FFA Q3 | 1.16 | (1.06–1.28) | 1.20 | (1.08–1.32) | |
| FFA Q4 | 1.30 | (1.18–1.43) | 1.34 | (1.21–1.48) | |
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| FFA per SD | 1.12 | (1.08–1.16) | 1.14 | (1.09–1.18) | |
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| FABP4 Q1 (Reference) | 3555 | 1.00 | 1.00 | ||
| FABP4 Q2 | 1.16 | (1.05–1.27) | 1.07 | (0.97–1.18) | |
| FABP4 Q3 | 1.19 | (1.08–1.32) | 1.05 | (0.94–1.17) | |
| FABP4 Q4 | 1.51 | (1.36–1.68) | 1.13 | (0.99–1.28) | |
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| FABP4 per SD | 1.21 | (1.17–1.25) | 1.04 | (0.98–1.09) | |
FABP4=fatty acid-binding protein 4; FFA=free fatty acids, HDL=high density lipoprotein; HR=hazard ratio; LDL=low density lipoprotein; SD=standard deviation SD of FFA = 0.2mEq/L. SD of FABP4 = 18.9ng/mL. Total person-years = 54167. Model 1: adjusted for age, sex, race, clinic and education (n = 4707). Model 2: adjusted for age, sex, race, clinic, education, BMI, cystatin C, albumin, physical activity, alcohol intake, smoking, hormone replacement therapy, self-reported health status, systolic blood pressure, LDL cholesterol, HDL cholesterol, hypertensive medication and lipid-lowering medication (n=4620).