Table 3.

Hazard ratios for cause-specific mortality per SD of FFA in Cardiovascular Health Study

	Number of vents	HR	Model 1 95% CI	p-value	HR	Model 2 95% CI	p-value
Cardiovascular	1,155	1.08	(1.01, 1.14)	0.02	1.08	(1.01, 1.15)	0.02
Cancer	729	1.02	(0.95, 1.11)	0.55	1.05	(0.96, 1.14)	0.29
Dementia	502	1.27	(1.16, 1.39)	<0.001	1.32	(1.20, 1.44)	<0.001
Infection	288	1.23	(1.09, 1.38)	0.001	1.25	(1.10, 1.41)	0.001
Respiratory	199	1.26	(1.10, 1.45)	0.001	1.23	(1.06, 1.43)	0.007
Trauma	156	0.97	(0.82, 1.16)	0.77	0.99	(0.83, 1.19)	0.93
Other	322	1.11	(0.99, 1.24)	0.08	1.16	(1.03, 1.31)	0.02

CI=confidence interval; FFA=free fatty acids, HR=hazard ratio; SD=standard deviation SD of FFA = 0.2mEq/L. Total person-years = 54,167. Model 1: adjusted for age, sex, race, clinic and education (n = 4707). Model 2: adjusted for age, sex, race, clinic, education, BMI, cystatin C, albumin, physical activity, alcohol intake, smoking, hormone replacement therapy, self-reported health status, systolic blood pressure, LDL cholesterol, HDL cholesterol, hypertensive medication and lipid-lowering medication (n = 4620). Types of mortality were defined as: cardiovascular (coronary heart disease, stroke, or other atherosclerotic disease), cancer (any type), dementia, infection (pneumonia, sepsis or other infection), respiratory, trauma (includes fractures) or other (liver disease, gastrointestinal disease, renal failure, ALS, Parkinson’s disease, bladder disease, metabolic conditions, amyloid, failure to thrive, myelodysplastic syndrome, and other musculoskeletal diseases).