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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Cell Calcium. 2014 Aug 10;56(3):125–132. doi: 10.1016/j.ceca.2014.08.002

Figure 4. Close-up view of the TM region of IP3R1.

Figure 4

(A) Cryo-EM densities of two opposing subunits of IP3R1 are shown as a side view. Identified α-helices are annotated with cylinders and labeled as in [9]. Scale bar is 50 Å. (B-D) X-ray structure of the eukaryotic Kir2.2 (PDB ID:3JYC) is shown as a ribbon and superimposed with the secondary structure elements identified in the TM region of IP3R1. (B) Two subunits are viewed along the membrane plane. Four subunits are viewed along the channel central axis from the luminal side (C) and from the cytoplasmic side (D).