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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Cell Immunol. 2014 Mar 12;291(0):16–21. doi: 10.1016/j.cellimm.2014.02.008

Figure 1.

Figure 1

The monocyte development pathway. Monocytes are derived from HSC in the bone marrow and spleen via several myeloid-restricted progenitors. Sca-1+ HSC (a) give rise to CD34+ CMP (b). These cells in turn give rise to CD34+CD16/32+ GMP (c). A population of these precursors also expresses CD115, CX3CR1 and Flt-3, known as the MDP (d). A recently identified monocyte precursor downstream of the MDP loses expression of Flt-3 and upregulates Ly6C, known as the cMoP (e). This cell gives rise to Ly6Chi monocytes (f), which have also been shown to differentiate into Ly6Clo monocytes (g).