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. 1971 Sep;4(3):205–211. doi: 10.1128/iai.4.3.205-211.1971

Immunobiological Activity of Cell Wall Antigens of Staphylococcus aureus

J J Kowalski a,1, David T Berman a
PMCID: PMC416289  PMID: 5154883

Abstract

Guinea pigs sensitized with washed, Formalin-killed cells of Staphylococcus aureus, strains 263 or Copenhagen, were skin-tested with various antigens from these strains including washed viable and heat-killed whole cells, cell walls, the peptidoglycan complexes of the walls, teichoic acid, teichoic acid-peptidoglycan fragments, and peptidoglycan fragments. In nonsensitized control animals, all antigens but teichoic acid elicited acute inflammatory reactions which decreased in size after 10 hr. In animals sensitized with the Copenhagen strain, the reactions to all antigens but teichoic acid and peptidoglycan fragments from either strain remained erythematous and indurated for at least 30 hr and were interpreted as hypersensitivity of the delayed type. Responses in animals sensitized with strain 263 generally resembled those in controls, although in some experiments there was evidence of hypersensitivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdulla E. M., Schwab J. H. Biological properties of streptococcal cell-wall particles. 3. Dermonecrotic reaction to cell-wall mucopeptides. J Bacteriol. 1966 Jan;91(1):374–383. doi: 10.1128/jb.91.1.374-383.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Agarwal D. S. Subcutaneous staphylococcal infection in mice. I. The role of cotton-dust in enhancing infection. Br J Exp Pathol. 1967 Aug;48(4):436–449. [PMC free article] [PubMed] [Google Scholar]
  3. DAVISON A. L., BADDILEY J., HOFSTAD T., LOSNEGARD N., OEDING P. SEROLOGICAL INVESTIGATIONS ON TEICHOIC ACIDS FROM THE WALLS OF STAPHYLOCOCCI. Nature. 1964 May 30;202:872–874. doi: 10.1038/202872a0. [DOI] [PubMed] [Google Scholar]
  4. DERBYSHIRE J. B. Studies in immunity to experimental staphylococcal mastitis in the goat and cow. J Comp Pathol. 1960 Apr;70:222–231. doi: 10.1016/s0368-1742(60)80023-9. [DOI] [PubMed] [Google Scholar]
  5. Dannenberg A. M., Jr Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes. Bacteriol Rev. 1968 Jun;32(2):85–102. doi: 10.1128/br.32.2.85-102.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ekstedt R. D. Studies on immunity to staphylococcal infection in mice. IV. The role of specific and nonspecific immunity. J Infect Dis. 1966 Oct;116(4):514–522. doi: 10.1093/infdis/116.4.514. [DOI] [PubMed] [Google Scholar]
  7. Ghuysen J. M. Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism. Bacteriol Rev. 1968 Dec;32(4 Pt 2):425–464. [PMC free article] [PubMed] [Google Scholar]
  8. Hill M. J. A staphylococcal aggressin. J Med Microbiol. 1968 Aug;1(1):31–43. doi: 10.1099/00222615-1-1-33. [DOI] [PubMed] [Google Scholar]
  9. JOHANOVSKY J. Role of hypersensitivity in experimental staphylococcal infection. Nature. 1958 Nov 22;182(4647):1454–1454. doi: 10.1038/1821454a0. [DOI] [PubMed] [Google Scholar]
  10. Kowalski J. J., Tipper D. J., Berman D. T. Preparation of Cell Wall Antigens of Staphylococcus aureus. Infect Immun. 1970 Jul;2(1):54–59. doi: 10.1128/iai.2.1.54-59.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mageau R. P., Roberson B. S. Association of toxic capsule and cell wall mucopeptide with virulence in Gaffkya tetragena. J Bacteriol. 1969 Jan;97(1):16–22. doi: 10.1128/jb.97.1.16-22.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Martin R. R., Crowder J. G., White A. Human reactions to staphylococcal antigens. A possible role of leukocyte lysosomal enzymes. J Immunol. 1967 Aug;99(2):269–275. [PubMed] [Google Scholar]
  13. Mudd S., Taubler J. H., Baker A. G. Delayed-type hypersensitivity to Staphylococcus aureus in human subjects. J Reticuloendothel Soc. 1970 Nov;8(5):493–498. [PubMed] [Google Scholar]
  14. Nathenson S. G., Ishimoto N., Anderson J. S., Strominger J. L. Enzymatic synthesis and immunochemistry of alpha- and beta-N-acetylglucosaminylribitol linkages in teichoic acids from several strains of Staphylococcus aureus. J Biol Chem. 1966 Feb 10;241(3):651–658. [PubMed] [Google Scholar]
  15. ROBERSON B. S., SCHWAB J. H., CROMARTIE W. J. Relation of particle size of C polysaccharide complexes of group A streptococci to toxic effects on connective tissue. J Exp Med. 1960 Nov 1;112:751–764. doi: 10.1084/jem.112.5.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schuster G. S., Hayashi J. A., Bahn A. N. Toxic properties of the cell wall of gram-positive bacteria. J Bacteriol. 1967 Jan;93(1):47–52. doi: 10.1128/jb.93.1.47-52.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Taubler J. H. Staphylococcal delayed hypersensitivity in mice. I. Induction and in vivo demonstration of delayed hypersensitivity. J Immunol. 1968 Sep;101(3):546–549. [PubMed] [Google Scholar]

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