Table 1.
Cluster statistics for cross-sectional group comparison
| cl. | Visit 1 | Visit 2 | Visit 3 | Visit 1 (QC) | Visit 2 (QC) | Visit 3 (QC) | ||
|---|---|---|---|---|---|---|---|---|
| 1 | basal ganglia | R | 4,337 | 5,143 | 4,491 | 4,579 | 5,356 | 4,551 |
| MNI (x/y/z) | 20/-6/-2 | 18/-7/-2 | 20/-7/-1 | 21/-6/-2 | 19/-8/-2 | 23/3/3 | ||
| 2 | basal ganglia | L | 3,997 | 2,574 | 2,553 | 4,287 | 2,873 | 2,571 |
| MNI (x/y/z) | −19/-8/-3 | −18/-7/-4 | −25/2/7 | −19/-8/-3 | −25/3/7 | −24/3/6 | ||
| 3 | thalamic region internal capsule | R/L | 40,800 | 1,617 | 84,048 | 7,961 | 1,665 | 5,560 |
| MNI (x/y/z) | 34/-17/-13 | 34/-18/-11 | 35/-19/-12 | 35/-18/-12 | 34/-18/-11 | 35/-18/-12 | ||
| 4 | thalamic region | R | within cl. 3 | within cl. 11 | within cl. 3 | 32,070 | 1,289 | within cl. 11 |
| MNI (x/y/z) | −3/-14/4 | −19/-10/9 | ||||||
| 5 | thalamic region | R | within cl. 3 | within cl. 11 | within cl. 3 | 1,859 | within cl. 11 | within cl. 11 |
| MNI (x/y/z) | 25/4/-13 | |||||||
| 6 | thalamic region | R | 1,072 | within cl. 11 | within cl. 3 | 738 | within cl. 11 | within cl. 11 |
| MNI (x/y/z) | 16/-40/4 | 16/-41/4 | ||||||
| 7 | thalamic region | L | 13,094 | 4,770 | within cl. 3 | 11,640 | 2,743 | 4,622 |
| MNI (x/y/z) | −21/-21/-15 | −20/-22/-13 | −21/-21/-13 | −20/-22/-13 | −23/-21/-11 | |||
| 8 | internal capsule | L | within cl. 7 | 432 | within cl. 3 | within cl. 7 | 335 | within cl. 11 |
| MNI (x/y/z) | 18/-9/12 | 18/-9/12 | ||||||
| 9 | external capsule | L | within cl. 7 | within cl. 11 | within cl. 3 | within cl. 7 | 1,406 | within cl. 11 |
| MNI (x/y/z) | −35/-15/7 | |||||||
| 10 | external capsule | R | 255 | within cl. 11 | within cl. 3 | 272 | within cl. 11 | within cl. 11 |
| MNI (x/y/z) | 36/-13/8 | 34/7/2 | ||||||
| 11 | CC | R/L | 1,400 | 41,508 | within cl. 3 | 3426 | 35,008 | 37705 |
| MNI (x/y/z) | −9/18/12 | −11/-25/25 | −7/17/13 | −11/-25/25 | −27/-56/19 | |||
| 12 | occipital lobe | R | 2,210 | 2,026 | 3,166 | 2,160 | 2,015 | 1,845 |
| MNI (x/y/z) | 35/-89/-8 | 38/-74/-5 | 38/-71/-7 | 34/-88/-8 | 38/-75/-4 | 37/-73/-6 | ||
| 13 | occipital lobe | L | 1,685 | 1,027 | within cl. 3 | 2,010 | 950 | 891 |
| MNI (x/y/z) | −40/-68/2 | −39/-69/2 | −41/-68/1 | −39/-69/2 | −40/-67/1 | |||
| 14 | frontal lobe | L | no cluster | 294 | 497 | 373 | 280 | 453 |
| MNI (x/y/z) | −34/27/6 | −41/29/-1 | −40/29/1 | −34/27/6 | −41/29/-1 | |||
| 15 | limbic lobe | L | no cluster | no cluster | within cl. 11 | 296 | 422 | within cl. 11 |
| MNI (x/y/z) | −16/0/37 | −15/3/35 | ||||||
| 16 | parietal lobe | L | 682 | no cluster | within cl. 11 | within cl. 3 | within cl. 11 | within cl. 11 |
| MNI (x/y/z) | −18/-49/34 | |||||||
| 17 | occipital lobe | L | 643 | 319 | within cl. 3 | 283 | 307 | within cl. 13 |
| MNI (x/y/z) | −22/-81/22 | −22/-80/24 | −23/-82/22 | −22/-80/23 | ||||
| 18 | temporal lobe | L | 205 | no cluster | within cl. 3 | 172 | 1279 | 203 |
| MNI (x/y/z) | −46/-52/3 | −47/-50/3 | −48/-53/5 | −46/-51/7 | ||||
| 19 | parietal lobe | R | 230 | no cluster | 311 | 256 | no cluster | 317 |
| MNI (x/y/z) | 19/-64/49 | 19/-61/47 | 19/-62/50 | 18/-63/49 | ||||
| 20 | internal capsule | R/L | 195 | no cluster | no cluster | no cluster | no cluster | no cluster |
| MNI (x/y/z) | −10/6/-6 | |||||||
| 21 | hippocampus | R | 192 | no cluster | no cluster | no cluster | no cluster | no cluster |
| MNI (x/y/z) | L | −26/-20/-26 |
Clusters (cl.) of the FA map group comparison between HD subjects and controls (cl. size/voxels and MNI coordinates of the area with highest significance). All clusters listed in this table show a p-value of p < 0.001. Basically, several cluster groups that are interconnected in different analyses were found. Clusters 1,2 (FA increase): clusters located in the basal ganglia. Clusters 3-17 (FA reduction): clusters covering the thalamic area, external and internal capsule, and corpus callosum (CC); additional clusters in the occipital, frontal, parietal lobe, and limbic regions. Clusters 18-21 (FA reduction): small clusters in the temporal and parietal lobe, the internal capsule, and the hippocampus.