Table 1.
Deregulated oncogenic or tumour suppressive miRNAs in 2102Ep and NTera-2 cells with an upregulated or downregulated profile in undifferentiated or differentiated hESC data from Stadler et al. [45]
| 2102Ep | hESC undifferentiated | hESC differentiated | ||
|---|---|---|---|---|
| OncomiR | Downregulated | miR-519c | Upregulated | Downregualted |
| miR-19a | miR-519d | miR-24 | miR-26a | |
| miR-512-5p | miR-520a* | miR-31 | ||
| miR-517a | miR-520b | miR-125b | ||
| miR-517b | miR-520f | mir-182 | ||
| miR-517c | miR-520 g | miR-221 | ||
| miR-518b | miR-520 h | |||
| miR-518f | ||||
| miR-525 | ||||
| Tumour Suppressor miRNA | Downregulated | Upregulated | Downregulated | |
| miR-148a | miR-424 | miR-26a | ||
| miR-27b | miR-31 | |||
| miR-28 | miR-125b | |||
| miR-30d | ||||
| miR-149 | ||||
| miR-331 | ||||
| NTera-2 | hESC undifferentiated | hESC differentiated | ||
| OncomiR | Downregulated | Upregulated | Downregulated | |
| miR-18a | miR-193b | miR-22 | ||
| miR-19a | miR-125b | |||
| miR-19b | miR-221 | |||
| miR-367 | miR-222 | |||
| miR-374 | ||||
| miR-517c | ||||
| Tumour Suppressor miRNA | Upregulated | Downregulated | ||
| miR-145 | miR-22 | |||
| miR-193b | miR-31 | |||
| miR-125b | ||||
| miR-34c | ||||
The individual titles ‘Downregulated’ and ‘Upregulated’ indicate the differential expression of each miRNA after SOX2 knock-down in either 2102Ep or NTera-2 cell lines or both.