Table 2.
Significantly represented miRNAs in 2102Ep and NTera-2 data with their associated targets
| Cell line | miRNA | Fold change | Targets |
|---|---|---|---|
| 2102Ep | miR-148a | -3.63 | ARRDC3 [58], ATP2B4, CHD7, ELMO1, FAM123B, H2AFY, HDGF, HMGA2, IL6ST, ITGA5 [59], ITGB8 [59], LIX1, NRP1, PREX1, TEAD1, TMEM54 |
| mir-26a | -1.73 | ADAM19, AMOT, CDH2, CDH11, CSNK1G1, ENC1, ENPEP, HAS2, HMGA2 [60], HOXA5 [61], HOXA9, LHX1, ITGA5, ITGB8, LEF1 [62], LIFR, MAP2 [63], NID1, NRIP1, PLXNA2, PRTG, SSFA2, TFAP2A, USP3, WNT5A, ZSWIM6 | |
| miR-200b | -1.48 | AHNAK, ARRDC3, CDH11, CNKSR3, CNTFR, EFNA1 [64], EMP1, FN1 [65], GATA2 [66], GLI3, HEG1, HOXA5, KIAA0101, MAP2, MBNL3, NKD1, NRIP1, NRP2, NTF3, PLXNA2, PRTG, ST6GALNAC5, TEAD1, TFAP2A [67], WWC3, ZEB2 [68] | |
| miR-30c | -1.23 | ACTC1, ADAM19, ADAMTS9, AHNAK, CAMK2N1, CHD7, CSNK1G1, CYP24A1, ELMO1, FAM123B, GRHL2, ITGA5, KIAA1024, LHX1, LIFR, MBNL3, NID1, NRIP1, NRP2, PLXNA2, PRTG, RARG, RASGRP3, RHOB, SNAI1 [69], SNAI2, TBL1X, TEAD1, TIMP3, ZEB2, ZSWIM6 | |
| miR-28 | 1.71 | DPF1 , IQSEC2, PRUNE2 | |
| miR-517b | -1.94 | CACNG4, HOXA5, NKD1, PRTG, ZEB2, ZNF436 | |
| miR-518a-3p | -2.47 | FRAS1, IL13RA1, TEAD1, TGFBR3 | |
| miR-518b | -2.06 | ||
| miR-518c | -3.33 | ||
| miR-518f | -1.87 | ||
| NTera-2 | miR-200c | -1.80 | AHNAK, CITED2, MBNL3, NTF3 [70], PLXNA2, PRTG, SEMA6D [71], YPEL2 |
| miR-367 | -1.46 | ATP2B4, CADM2, EOMES, HAND1, MBNL3, PKDCC, SEMA6D, SESN3 |
Genes in bold are previously confirmed targets of their respective miRNAs which also showed up in our data. Genes in cursive style are predicted by TargetScan and either microT-CDS or miRanda (August 2010 Release). All other genes were predicted by all three prediction tools.