Table 3.

MiRNAs with SOX2-binding sites in hESCs which were deregulated in 2102Ep and NTera-2 cells

	Precursor	Mature miRNA	Fold-change	Distance to TSS	Expression EMT/MET	Validated targets × hECC data
2102Ep	hsa-mir-9-2	miR-9*	5.16	1887
	hsa-mir-9-2	miR-9	3.83	1887	Up in EMT [80]	CDX2, ID2
	hsa-mir-181a-2	miR-181a-2*	3.05	-467
	hsa-mir-424	miR-424	2.87	3042	Up in EMT [81]
	hsa-mir-301a	miR-301	1.78	55
	hsa-mir-182	miR-182	-2.08	-4286	Up in MET [82]	RARG, SNAI2
	hsa-mir-942	miR-942	-2.10	-126
	hsa-mir-183	miR-183*	-2.32	-4286
	hsa-mir-183	miR-183	-2.90	-4286	Down in EMT [83]	SNAI2
	hsa-mir-135b	miR-135b*	-3.04	4448
	hsa-mir-766	miR-766	-5.04	-1234
NTera-2	hsa-mir-19b-2	miR-19b	-1.35	-932		PRUNE2
	hsa-mir-22	miR-22	-1.58	-186	Up in EMT [84]
	hsa-mir-324	miR-324-5p	-1.91	-2058		AHNAK
	hsa-mir-124-2	miR-124	-1.98	-5	Down in EMT [85]
	hsa-mir-22	miR-22*	-2.02	-186
	hsa-mir-7-1/7-3	miR-7	-2.27	-2262	Down in EMT [86]
	hsa-mir-135b	miR-135b*	-2.33	4448
	hsa-mir-135b	miR-135b	-2.56	4448
	hsa-mir-181a-2	miR-181a	-2.61	-467	Up in EMT [87]	NANOG
	hsa-mir-577	miR-577	-3.31	1455
	hsa-mir-181a-2	miR-181a-2*	-4.47	-467
	hsa-mir-1251	miR-1251	-7.90	1717