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The results of the genetic analysis of MLH1. a Direct sequencing of MLH1 revealed that the patient harbored a germline mutation in MLH1, c.209_211delAAG, which resulted in exon 3 skipping. b Reverse transcriptase polymerase chain reaction (RT-PCR) of MLH1 messenger RNA (mRNA) revealed a shorter product [skipping of exon 3 (99 bp)] in the present case (lane 2 HNPCC). MW denotes the molecular weight marker. Control denotes the RT-PCR product obtained from normal MLH1 mRNA
