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. 2013 Dec 8;106(2):45–56. doi: 10.1111/boc.201300069

Figure 2. Regulators and effectors of WNK–OSR1/SPAK kinase signaling.

Figure 2

NaCl and K intakes regulate WNK kinase–OSR1/SPAK-NCC signaling in the kidney. Angiotensin II, aldosterone, vasopressin, and insulin also regulate WNK–OSR1/SPAK–NCC signaling in the kidney. A WNK1/WNK3–SPAK–Na-K-2Cl-cotransporter 1 cascade regulates arterial tonus.