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. Author manuscript; available in PMC: 2015 Sep 11.
Published in final edited form as: Cell. 2014 Sep 11;158(6):1324–1334. doi: 10.1016/j.cell.2014.07.040

Figure 1. Protection of cultured U2OS cells from doxorubicin-mediated toxicity by active derivatives of P7C3.

Figure 1

(A) U2OS cells were treated with 5μM P7C3-A20 for 2 h prior to incubation with the indicated concentrations of doxorubicin for 72h. (B) Comparison of the P7C3-S243 enantiomers in protection of cells from doxorubicin revealed that (−)-P7C3-S243 was more active than (+)-P7C3-S243, consistent with their respective neuroprotective activities in vivo (see text). In all cell survival graphs, data are expressed as mean ± standard deviation (SD) of experimental duplicates. See also Figure S1, S2 and S3, and Table S1.