(A) Bead-immobilized Hrd1p (1 μM) was ubiquitinated and incubated at different
salt conditions with 2 μM of the indicated components (UN, Ufd1p/Npl4p) in the
presence of 250 μM ATPγS. The bound material was analyzed by SDS-PAGE and
staining with IRDye Blue.
(B) As in (A), but bead-immobilized Hrd1p was modified with methylated ubiquitin.
(C) As in (A), but with non-ubiquitinated Hrd1p.
See also Figure S3.