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HCV cellular replicon data for all d-amino acid analog of complex 1-Cu.
| Compound | Antiviral IC50 (µM) |
Cytotoxicity TC50 (µM) |
Selectivity Index (TI) |
|---|---|---|---|
| [GGHYrFK-amide]-Cu2+, 1-Cu | 0.6 ± 0.3 | > 100 | > 172 |
| [GGhyrfk-amide]-Cu2+, 2-Cu | 1.9 ± 0.4 | > 100 | >52 |
| YrFK-amide | > 100 | > 100 | na |
| yrfk-amide | > 100 | > 100 | na |
| [GGH]-Cu2+ | > 100 | > 100 | na |
| Cu2+(aq) | > 100 | > 100 | na |
na = not applicable
