Summary of results A.
Pain-free and headache relief
| Studies | Attacks treated | Treatment (%) | Placebo or comparator (%) | NNT/NNTp (95% CI) | P for difference | |
|---|---|---|---|---|---|---|
| Pain-free at 2 hours | ||||||
| Aspirin 900 or 1000 mg versus placebo | 6 | 2027 | 24 | 11 | 8.1 (6.4 to 11) | z = 0.3051 P = 0.76 |
| Aspirin 900 mg plus metoclopramide 10 mg versus placebo | 2 | 519 | 18 | 7 | 8.8 (5.9 to 17) | |
| Aspirin 1000 mg versus sumatriptan 50 mg | 2 | 726 | 26 | 32 | Not calculated | |
| Aspirin 900mg + metoclopramide 10 mg versus sumatriptan 100 mg | 2 | 528 | 18 | 28 | 9.8 (5.8 to 32) | |
| Headache relief at 1 hour | ||||||
| Aspirin 900 or 1000 mg versus placebo | 4 | 1288 | 37 | 15 | 4.7 (3.8 to 5.9) | |
| Aspirin 1000 mg versus sumatriptan 50 mg | 2 | 726 | 38 | 24 | 7.2 (4.9 to 14) | |
| Headache relief at 2 hours | ||||||
| Aspirin 900 or 1000 mg versus placebo | 6 | 2027 | 52 | 32 | 4.9 (4.1 to 6.2) | z = 2.4847 P = 0.013 |
| Aspirin 900 mg plus metoclopramide 10 mg versus placebo | 3 | 765 | 57 | 26 | 3.3 (2.7 to 4.2) | |
| Aspirin 1000 mg versus sumatriptan 50 mg | 2 | 522 | 51 | 53 | Not calculated | |
| Aspirin 900mg + metoclopramide 10 mg versus sumatriptan 100 mg | 2 | 523 | 51 | 54 | Not calculated | |
| Sustained headache relief at 24 hours | ||||||
| Aspirin 1000 mg versus placebo | 3 | 1142 | 39 | 24 | 6.6 (4.9 to 10) | z = 0.7789 P = 0.43 |
| Aspirin 900 mg plus metoclopramide 10 mg versus placebo | 1 | 257 | 37 | 17 | 6.2 (4.8 to 8.9) |